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Novel aspects of grapevine response to phytoplasma infection investigated by a proteomic and phospho-proteomic approach with data integration into functional networks
Margaria Paolo,Abbà Simona,Palmano Sabrina
BMC Genomics , 2013, DOI: 10.1186/1471-2164-14-38
Abstract: Background Translational and post-translational protein modifications play a key role in the response of plants to pathogen infection. Among the latter, phosphorylation is critical in modulating protein structure, localization and interaction with other partners. In this work, we used a multiplex staining approach with 2D gels to study quantitative changes in the proteome and phosphoproteome of Flavescence dorée-affected and recovered ‘Barbera’ grapevines, compared to healthy plants. Results We identified 48 proteins that differentially changed in abundance, phosphorylation, or both in response to Flavescence dorée phytoplasma infection. Most of them did not show any significant difference in recovered plants, which, by contrast, were characterized by changes in abundance, phosphorylation, or both for 17 proteins not detected in infected plants. Some enzymes involved in the antioxidant response that were up-regulated in infected plants, such as isocitrate dehydrogenase and glutathione S-transferase, returned to healthy-state levels in recovered plants. Others belonging to the same functional category were even down-regulated in recovered plants (oxidoreductase GLYR1 and ascorbate peroxidase). Our proteomic approach thus agreed with previously published biochemical and RT-qPCR data which reported down-regulation of scavenging enzymes and accumulation of H2O2 in recovered plants, possibly suggesting a role for this molecule in remission from infection. Fifteen differentially phosphorylated proteins (| ratio | > 2, p < 0.05) were identified in infected compared to healthy plants, including proteins involved in photosynthesis, response to stress and the antioxidant system. Many were not differentially phosphorylated in recovered compared to healthy plants, pointing to their specific role in responding to infection, followed by a return to a steady-state phosphorylation level after remission of symptoms. Gene ontology (GO) enrichment and statistical analysis showed that the general main category “response to stimulus” was over-represented in both infected and recovered plants but, in the latter, the specific child category “response to biotic stimulus” was no longer found, suggesting a return to steady-state levels for those proteins specifically required for defence against pathogens. Conclusions Proteomic data were integrated into biological networks and their interactions were represented through a hypothetical model, showing the effects of protein modulation on primary metabolic ways and related secondary pathways. By following a multiplex-stain
Localization of cassava brown streak virus in Nicotiana rustica and cassava Manihot esculenta (Crantz) using RNAscope？ in situ hybridization
Elijah M. Ateka,Esperance Munganyinka,Fred Tairo,Joseph Ndunguru,Paolo Margaria,Samar Sheat,Stephan Winter
- , 2018, DOI: 10.1186/s12985-018-1038-z
Abstract:
El concilio Vaticano II y su impacto en el campo episcopal argentino
Margaria,Paulo;
Trabajo y sociedad , 2012,
Abstract: this article examines the impact that second vatican council had on argentinian catholic church, with special emphasis on the bishops field, from a socio-religious perspective that seeks to explain the complexity of catholic field. therefore, it seems appropriate to use the pierre bourdieu's notion of "field". we believe that talk about "religious field" allows us to conceive catholicism as a dynamic social space spanned by constant conflicts and struggles carried out by groups of agents who tried to dominate the field. again, this allows us to characterize the positions that the council emphasized in the argentine catholicism, acting as a propellant and legitimizing ideas and conflicts that existed previously.
Finally one minister of the health woman and mother
E. Margaria
Pathos : Trimestrale di Algologia , 2006,
Abstract:
El concilio Vaticano II y su impacto en el campo episcopal argentino The Second Vatican Council and its impact on argentinian Episcopal field
Paulo Margaria
Trabajo y sociedad , 2012,
Abstract: El presente artículo busca explorar el impacto que tuvo el Concilio Vaticano II en la Iglesia Católica Argentina, haciendo especial hincapié en el campo de los obispos, desde una perspectiva socio-religiosa que pretende dar cuenta de la complejidad del campo católico. Para ello nos parece adecuado utilizar la noción de "campo" en términos bourdianos. Consideramos que hablar de "campo religioso" nos permite concebir el catolicismo como un espacio social dinámico y atravesado por constantes conflictos y luchas llevadas a cabo por grupos de agentes que intentan dominar dicho campo. Esto nos permitirá caracterizar las diversas posturas que el Concilio acentuará en el catolicismo argentino, actuando de este modo como un propulsor y legitimador de reflexiones y conflictos que existían previamente. This article examines the impact that Second Vatican Council had on argentinian Catholic Church, with special emphasis on the Bishops field, from a socio-religious perspective that seeks to explain the complexity of Catholic field. Therefore, it seems appropriate to use the Pierre Bourdieu's notion of "field". We believe that talk about "religious field" allows us to conceive Catholicism as a dynamic social space spanned by constant conflicts and struggles carried out by groups of agents who tried to dominate the field. Again, this allows us to characterize the positions that the Council emphasized in the Argentine Catholicism, acting as a propellant and legitimizing ideas and conflicts that existed previously.
On the Impact of Channel Cross-Correlations in High-Sensitivity Receivers for Galileo E1 OS and GPS L1C Signals
Davide Margaria,Beatrice Motella,Fabio Dovis
International Journal of Navigation and Observation , 2012, DOI: 10.1155/2012/132078
Abstract: One of the most promising features of the modernized global navigation satellite systems signals is the presence of pilot channels that, being data-transition free, allow for increasing the coherent integration time of the receivers. Generally speaking, the increased integration time allows to better average the thermal noise component, thus improving the postcorrelation SNR of the receiver in the acquisition phase. On the other hand, for a standalone receiver which is not aided or assisted, the acquisition architecture requires that only the pilot channel is processed, at least during the first steps of the procedure. The aim of this paper is to present a detailed investigation on the impact of the code cross-correlation properties in the reception of Galileo E1 Open Service and GPS L1C civil signals. Analytical and simulation results demonstrate that the S-curve of the code synchronization loop can be affected by a bias around the lock point. This effect depends on the code cross-correlation properties and on the receiver setup. Furthermore, in these cases, the sensitivity of the receiver to other error sources might increase, and the paper shows how in presence of an interfering signal the pseudorange bias can be magnified and lead to relevant performance degradation. 1. Introduction In the context of Global Navigation Satellite Systems (GNSS) receivers, the interest on the new modulations that will be used for the modernized GPS L1C and Galileo E1 Open Service (OS) civil signals grew rapidly in past years. The definition of new signals structure results from an agreement between the European Commission and Unites States of America. A common Multiplexed Binary Offset Carrier Modulation (MBOC) signal baseline has been adopted, with the aim of assuring the compatibility and interoperability between GPS and Galileo systems [1]. For the GPS L1C signal, USA has chosen the Time Multiplexed BOC (TMBOC) solution that multiplexes a BOC(1,1) with a BOC(6,1) in time domain [2], while the composite BOC (CBOC) is the implementation selected for the Galileo E1 OS Signal In Space (SIS) [3]. One of the main features of the modernized civil and open access signals is the presence of the pilot channels. Pilot channel has been introduced to allow the receivers to perform coherent integration over a long time, without facing the issue of unpredictable data transitions. As a consequence, the receiver is able to acquire satellite signals at lower SNR than the nominal value. In order to deal with such a need in current GPS receiver, assistance data have been defined and
Higher-Order Process Modeling: Product-Lining, Variability Modeling and Beyond
Johannes Neubauer,Bernhard Steffen,Tiziana Margaria
Computer Science , 2013, DOI: 10.4204/EPTCS.129.16
Abstract: We present a graphical and dynamic framework for binding and execution of business) process models. It is tailored to integrate 1) ad hoc processes modeled graphically, 2) third party services discovered in the (Inter)net, and 3) (dynamically) synthesized process chains that solve situation-specific tasks, with the synthesis taking place not only at design time, but also at runtime. Key to our approach is the introduction of type-safe stacked second-order execution contexts that allow for higher-order process modeling. Tamed by our underlying strict service-oriented notion of abstraction, this approach is tailored also to be used by application experts with little technical knowledge: users can select, modify, construct and then pass (component) processes during process execution as if they were data. We illustrate the impact and essence of our framework along a concrete, realistic (business) process modeling scenario: the development of Springer's browser-based Online Conference Service (OCS). The most advanced feature of our new framework allows one to combine online synthesis with the integration of the synthesized process into the running application. This ability leads to a particularly flexible way of implementing self-adaption, and to a particularly concise and powerful way of achieving variability not only at design time, but also at runtime.
A Method to Assess Robustness of GPS C/A Code in Presence of CW Interferences
Beatrice Motella,Simone Savasta,Davide Margaria,Fabio Dovis
International Journal of Navigation and Observation , 2010, DOI: 10.1155/2010/294525
Abstract: Navigation/positioning platforms integrated with wireless communication systems are being used in a rapidly growing number of new applications. The mutual benefits they can obtain from each other are intrinsically related to the interoperability level and to a properly designed coexistence. In this paper a new family of curves, called Interference Error Envelope (IEE), is used to assess the impact of possible interference due to other systems (e.g., communications) transmitting in close bandwidths to Global Navigation Satellite System (GNSS) signals. The focus is on the analysis of the GPS C/A code robustness against Continuous Wave (CW) interference. 1. Introduction In the last years navigation technology is becoming essential for several civil applications, some of them even unthinkable at the time of the satellite navigation starting. Alongside the wide use in the transports fields (e.g., aviation, maritime, rail, and road), the range of civil uses is constantly increasing. Surveying, precision agriculture, environmental protection, scientific research (e.g., monitoring geological change, wildlife behaviour, atmospheric modelling, oceanic studies, space exploration), time-based applications (e.g., line power or telecommunications network synchronization and management) are examples of the most various applications based on the estimation of the user Position, Velocity, and Time (PVT). This kind of applications, especially those devoted to safety, requires the coexistence of different communication systems and GNSS. The use of receivers able to provide multiple services, such as user position estimation and data transmission, embeds the problem of managing different systems with different specifications. Despite Wireless Communication Systems (WCSs) use of different carrier frequencies with respect to GNSS bands, they could likewise represent potential threats for GNSS modules integrated in personal devices and communication units. This is due to the low-received GNSS signal power [1, 2], which makes the systems vulnerable to potential dangerous effects caused by undesired and unintentional interfering signals that might appear in the GNSS bandwidths. These interferences could compromise the correct functioning of the main blocks of the GNSS receiver chain, such as acquisition and tracking stages. This fact would affect also the service based on the integrated communication/positioning system and might result in dangerous failures for those applications oriented to safety of life or as the ones involving financial transactions. For this reason, the
Mortality rate after hip hemiarthroplasty: analysis of risk factors in 299 consecutives cases
F. D’Angelo,M. Giudici,M. Molina,G. Margaria
Journal of Orthopaedics and Traumatology , 2005, DOI: 10.1007/s10195-005-0093-6
Abstract: Waiting for surgery was a significant factor for mortality at 6, 12 and 24 months: patients surgically treated in the first 24 hours had lower mortality than those who waited longer. The risk of mortality in the first 6 months doubled for an age increase of 12 years, while mortality within 2 years doubled for an age increase of 9 years. Although the motality rate after surgery for femoral neck fracture was high in the first year (25%), it dropped off in successive years to levels observed in a healthy population. Thus, we agree with the literature that femoral fracture is a risk factor for survival only in the first year after trauma, above all in the elderly.
Constraint-Guided Workflow Composition Based on the EDAM Ontology
Anna-Lena Lamprecht,Stefan Naujokat,Bernhard Steffen,Tiziana Margaria
Computer Science , 2010,
Abstract: Methods for the automatic composition of services into executable workflows need detailed knowledge about the application domain,in particular about the available services and their behavior in terms of input/output data descriptions. In this paper we discuss how the EMBRACE data and methods ontology (EDAM) can be used as background knowledge for the composition of bioinformatics workflows. We show by means of a small example domain that the EDAM knowledge facilitates finding possible workflows, but that additional knowledge is required to guide the search towards actually adequate solutions. We illustrate how the ability to flexibly formulate domain-specific and problem-specific constraints supports the work ow development process.
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